Explore Longevity Graded

An honest, evidence-graded tour of the longevity toolkit — what has human outcome RCTs versus what is animal or mechanistic-only.

NAD+ precursors reliably raise NAD+ but show modest, mixed human outcomes. Peptides and growth hormone carry real cautions. An honest evidence review.

Strong animal data, a glaring human RCT gap. What the PEARL pilot, the TAME rationale, and metformin's observational signal really show.

DTC and IV longevity clinics sit on the weakest evidence in the field. What a critical review found, and how to vet a provider before paying.

Rapamycin is the most reproducible lifespan extender in mice — but there is no human longevity trial. An honest split of the hype from the evidence.

PEARL was the largest decentralized RCT of rapamycin in healthy aging — and it missed its primary endpoint. An honest readout of what it did and didn't prove.

The longevity market splits into four bands: concierge clinics, membership programs, DTC labs, single-product Rx. What each delivers, and who it's for.

Epigenetic clocks (Horvath, GrimAge, DunedinPACE) predict aging well in populations — but are noisy and unproven for individuals. An honest evidence review.

NR and NMN reliably raise NAD+ in humans, but the trials mostly fail to show clinical or longevity outcomes. An honest review of the hype versus the data.

Longevity panels mix genuinely useful, outcome-validated markers (ApoB, HbA1c, hs-CRP) with vanity numbers. An honest, evidence-graded breakdown.

GLP-1 drugs have the strongest human outcome data in longevity — but it's cardiometabolic risk reduction, not proven lifespan extension. An honest review.

Most longevity peptides are sold on mechanism and anecdote, not human outcomes. An honest, citation-backed review of what the evidence actually supports.

Metformin's anti-aging case is mechanistic and observational — no completed RCT proves it. Why the TAME trial exists, and the exercise caveat.

Concierge clinics ($8k–$25k/yr) sell diagnostics; membership programs ($99–$300/mo) sell ongoing treatment. What each delivers, and where the money goes.

The five-factor, 14-point rubric behind every letter grade: price transparency, longevity line, oversight, pharmacy identification, and support.

We grade the popular longevity supplements — NMN, NR, spermidine, resveratrol, CoQ10, omega-3, vitamin D, fisetin, GlyNAC — on human evidence, not hype.

A longevity doctor blends preventive medicine, biomarker testing, and lifestyle coaching. What they really do, credentials to check, and who needs one.

Spermidine induces autophagy and dietary intake tracks with lower mortality — but the best human trial was negative. An honest, evidence-graded review.

The sitting-rising and sit-to-stand tests predict mortality in research — but they're markers of strength, balance, and flexibility, not a verdict.

Compare longevity care costs: annual lab memberships, recurring clinical care, prescriptions and imaging. Check the first charge, renewal and exclusions.

Free biological-age calculators range from validated (PhenoAge from a basic blood panel) to entertainment. An honest guide to what's worth your time.

A 2023 Science paper called taurine deficiency a driver of aging. A 2025 Science follow-up questioned its core premise. An honest, evidence-graded review.

Urolithin A (Mitopure) has the cleanest human-trial record of any mitochondrial supplement — modest muscle gains in RCTs. But healthspan isn't lifespan.

Fisetin was the standout senolytic flavonoid in mouse screens and extended lifespan ~10%. In humans, the longevity data are essentially zero. An honest review.

Baylor RCTs report GlyNAC corrects glutathione deficiency and several aging hallmarks in older adults. But the trials are small and the headlines overstate it.

The viral "8 years younger" AKG result came from a 42-person study with no placebo group and an unvalidated aging clock. An honest evidence review.

Dasatinib + quercetin is the first-in-human senolytic — with small IPF and kidney signals. But it's a chemo drug plus a flavonoid, with no longevity RCT yet.

Median VO2 max by age and sex from 16,278 lab treadmill tests, what counts as good for your age, and why low fitness carries risk on par with smoking.

In the 140,000-person PURE study, grip strength outpredicted systolic blood pressure for mortality. A genuinely strong, free, at-home biomarker.

ProLon's 5-day fasting-mimicking diet has real human trials behind it — but most are tied to its inventor's company. An honest, graded look.

One small Israeli trial reported HBOT lengthened telomeres 38% and cut senescent cells. It's striking, unreplicated, and expensive. An honest, graded review.

Creatine has the strongest human evidence of any longevity supplement — for healthspan, not lifespan. With resistance training it adds muscle and strength.

The hallmarks of aging are the cellular processes that drive getting old. A plain-English guide to the 2013 and 2023 framework — and why each one gets targeted.

Sulforaphane from broccoli extends lifespan in worms and activates Nrf2 — but the human longevity evidence is preclinical. An honest, evidence-graded review.

Glycine alone extended mouse lifespan ~6% in the ITP. But the dramatic 'reverses aging' results belong to the GlyNAC combo, not solo glycine. An honest review.

A 2025 Nature study tied lithium deficiency to Alzheimer's in mice. But that's mouse healthspan, not human lifespan — and lithium has a narrow safety window.

Ergothioneine has a strong observational link to lower mortality — but no human trial, and the signal may just track a healthy diet. An honest grade.

DO-HEALTH found 1 g/day omega-3 slowed epigenetic clocks by ~3–4 months. Real, randomized — but a small, surrogate effect. An honest evidence grade.

KiSel-10 showed CoQ10 plus selenium cut cardiovascular mortality in elderly Swedes — but the benefit is CV-specific, not lifespan. An honest grade.

GrimAge predicts mortality, PhenoAge predicts disease, DunedinPACE measures pace of aging. No clock is validated to guide your treatment. An honest comparison.

Compare Fountain Life and Human Longevity prices, care and follow-up. Understand why disease detection is different from a proven screening benefit.

Frequent sauna use is tied to ~40% lower all-cause mortality in Finnish men — but it's one observational cohort, not a randomized trial. An honest grade-B read.

Cold exposure extends lifespan in worms and flies — but there's zero human lifespan data, and the human evidence is about recovery and mood, not living longer.

Zone 2 has a strong mitochondrial mechanism and builds the fitness that predicts lifespan — but no trial proves Zone 2 itself extends life. Graded honestly.

Function, InsideTracker, Lifeforce, Superpower — graded honestly. The four cheap outcome-validated markers matter; the '100+ biomarker' count mostly doesn't.

Blood-methylation clocks are the only defensible at-home bio-age tier; saliva and telomere kits are noisier. None proves you're aging slower. Honestly graded.

A skeptical, evidence-graded review: the SIRT1 story was an artifact, a 2025 primate trial found no lifespan benefit, and oral resveratrol barely reaches cells.

Industry-funded trials show skin and joint benefits; independent reviews are cautious. Collagen digests to amino acids, and the longevity claim is unproven.

Quercetin's senolytic effect needs the dasatinib combination. Standalone quercetin has no human senolytic evidence — just modest anti-inflammatory effects.

Function Health vs Superpower, graded honestly: nearly identical 100+ lab memberships that both test without treating. The tiebreaker isn't the marker count.

STAMINA found favorable vascular markers after six months of NOVOS Core. Examine the published trial, incomplete follow-up and limits of its longevity claims.

NOVOS sells a multi-pathway longevity supplement; Tally Health sells an epigenetic-age test plus its own pill. A graded, honest head-to-head on what's proven.

Spermidine targets autophagy; fisetin clears senescent cells. Different mechanisms, different evidence grades — an honest, head-to-head longevity comparison.

Function casts a wide 160+ marker net; InsideTracker pairs fewer markers with an algorithm. We grade breadth, actionability, price — and who each fits.

GlyNAC adds N-acetylcysteine to glycine for glutathione restoration. Is the extra ingredient worth it for longevity? An honest, graded comparison.

Acarbose robustly extended mouse lifespan in the NIA's rigorous ITP — better replicated than most longevity drugs. But there are zero human longevity trials.

Time-restricted eating and 5:2 have strong animal data — but human trials show the benefit is mostly about eating less, not the clock. No lifespan proof.

Berberine activates AMPK like metformin and lowers glucose and lipids in humans — but its longevity evidence is animal-only. An honest look at the hype.

Testosterone therapy is a treatment for diagnosed hypogonadism. No trial shows it extends life. Here is what TRAVERSE, the T-Trials and the guidelines found.

Sermorelin prices depend on the plan and supply period. Compare published costs, growth-hormone research and the limits of its anti-aging claims.

Compare NAD+ injections, IV infusions and oral precursors: human evidence, route-specific limits and the costs to check before choosing.

NMN and NR have been compared in a human trial. See what blood NAD+ results, clinical studies and safety data do—and do not—show about longevity.

Hormone therapy treats menopausal symptoms and protects bone. Over 18 years of follow-up it did not change all-cause mortality. Timing changes the risk picture.

A human plasma-exchange trial changed biological-age markers. We examine its design, IVIG, safety and why clock changes do not prove longer life.

Sermorelin is a compounded peptide that makes your pituitary release growth hormone. Its FDA status, what studies show and what it costs at graded providers.

NAD+ injections run about $99 to $325 a month at the providers we grade. None is FDA-approved, and no outcome trial has tested injected or IV NAD+ for aging.

NAD+ injections cost about $99–$299 a month through telehealth. They are compounded, not FDA-approved, and no human trial has tested them for aging.

NAD+ IV drips commonly cause nausea and chest pressure if run fast, cost $299–$1,000 a session, and have no outcomes trial. Who places the line matters most.

What sermorelin trials measured week by week: growth hormone rises within minutes, IGF-1 within two weeks, and body changes were small and mostly seen in men.

Sermorelin's most common side effect is injection-site pain or redness, about 16% in pediatric trials. Other effects, who should avoid it, and cancer risk.

FDA linked 30+ IV glutathione reactions to a supplement-grade ingredient. What the injections do, what the evidence shows, and what to ask a provider.

TruDiagnostic's TruAge uses the well-validated DunedinPACE clock — but no test proves the score predicts YOUR outcomes. An honest, evidence-graded review.

Function Health's 160+ lab membership surfaces real outcome-validated markers — but roughly half are basic labs, and it tests without treating. Honest review.

Bryan Johnson's Blueprint is a single-subject experiment with no control group — and roughly 90% of its likely benefit is replicable diet, sleep, and exercise.

GlycanAge measures IgG glycans tied to inflammation, and they move with lifestyle — but independent validation is thin and it can't localize a problem. Graded.

Galleri's blood test can flag a cancer signal across many types — but no trial shows it saves lives, and false positives trigger costly cascades. Graded.

Attia's Outlive popularized Medicine 3.0 and the Four Horsemen. We grade the framework honestly: where the evidence is strong, and where it's reasoned opinion.

InsideTracker adds DNA and an 'InnerAge' score to blood panels. The core markers are real, but it's pricier per marker and recommendations skew to upsells.

Lifeforce bundles a clinician and Rx onto a ~50-marker quarterly panel for ~$149/mo. That crosses test-into-treat — but the panel is narrow and the upsell real.

Superpower's $349/yr membership ($299 the first year) runs 150+ lab tests over two draws. The useful core is small, the panel padded, treatment unpriced.

NOVOS Core has a published human vascular trial, but no proven lifespan benefit. Review its current formula, $109 single-box price and subscription terms.

Tally Health pairs a $249 TallyAge epigenetic test with action plans and a supplement. The clock is real science; tracking your own aging with it isn't proven.

AgelessRx runs real trials and charges no membership. Its flagship, rapamycin, now publishes a real monthly price — metformin and NAD+ still don't.

Hone prices every drug in plain sight and demands no commitment — but it sells hormone therapy as longevity care, which the label and the trials don't support.

He & She MD publishes a term ladder for every longevity product — and every figure it advertises is the twelve-month rung, not the monthly one.

Peter MD sells sermorelin at $585 a quarter and NAD+ at $369 a course. Its $79 TRT headline is the twelve-month rate; month-to-month is $139.

HumeCare+ bundles a body analyzer with compounded semaglutide and titrates against lean mass — and publishes no price until the medical intake is done.

CoreAge Rx review: NAD+ from $93, sermorelin from $99, a 503A claim, and conflicting refund and renewal terms. What to confirm before paying.

Shed advertises NAD+ from $144/mo. Its own terms require a two-month minimum and print the membership rate as an unfilled blank.

Sprout Health leads with $199 for NAD+. The recurring rate is $249 every four weeks. What that costs, what's included, and where it loses points.

Enhance MD advertises NAD+ at $169/mo. That rate needs a 12-month prepay; month-to-month is $199 injection or $99 wafers.

HealthRX advertises NAD+ at $161/mo and that is the month-to-month rate, not a prepay. What the price hides, and what it doesn't.

Direct Meds NAD+ is $249 or $299 a month on a 30-day supply, $199 or $249 on 90 days. Two of its pages name different compounding sections.

RxSpan MD prices NAD+ at $249/mo, falling to $150 on a 12-month plan. It names four dispensing pharmacies but classifies none of them.

Strut Health's $99 sermorelin and $149 NAD+ are auto-refill rates. The one-off price is 18% higher and is published nowhere.

yourEra prices NAD+ from $170/mo with no contract — genuinely month-to-month. It never says how the NAD+ is delivered.

Telos Rx names both dispensing pharmacies with addresses — and publishes no single-month price. "Cancel anytime, no penalties" isn't quite true.

MadeMed sells no month-to-month plan. NAD+ is $209/mo on a 3-month prepay ($627) or $199/mo on six ($1,194), after a CMP you pay for.

Try Ageless advertises NAD+ at $199 and sermorelin at $126 — both are intro-code rates, and the page says the final amount comes after review.

Gala now sells NAD+ and sermorelin at $199 a month with the visit and shipping included. It names no pharmacy, and refunds stop once you cancel.

Next Health publishes memberships from $99/mo to $100,000/yr — then bills NAD+ IVs at $500 on top. And two of its own price lists disagree.

Marek's intake is $299 and it requires a $450 minimum lab panel. Panels run $150–$1,950. What no page publishes is the price of the medicine.

CORE is listed at $10,500 and APEX at $23,500. Compare Fountain Life's published offers, cancer-test listings and the evidence behind broad screening.

Prenuvo's whole-body MRI costs $2,499. Compare scan and membership options, renewal rules, incidental findings and the limits of its cancer-detection data.

System Labs publishes NAD+ at $89 and sermorelin at $109 — both struck through from $149 and $219, both first-month rates. What that means.

Wellorithm's sermorelin page prints $150 first month, then $200/mo* — and is absent from its own nav and sitemap. What the asterisk means.

Winona publishes a real monthly price on every hormone product — but its own pages disagree on whether its HRT is FDA-approved.

Taurus names four pharmacies and prices its peptides — but Taurus TRT, its own namesake product, has no public price, and the Terms hide a $17.99 fee.

Revel prices NAD+ and sermorelin clearly, with dosage-independent pricing and a real refund policy — but no pharmacy is named anywhere.

Male Excel advertises TRT "starting at $95/month" — but a mandatory $99/month membership roughly doubles the real minimum.

Feel30's $149/month is genuinely all-inclusive, confirmed three times in its own FAQ — but it names no pharmacy.

Wellspring's own "Pricing" FAQ gives no number — just a comparison to retail. Its pharmacy is named, but only if you find the right FAQ answer.

CeliaRx prices NAD+, sermorelin and PT-141 individually — $399, $349, $349 — with no subscription tier, plus a separate $55 consult.

Nolu prices NAD+/sermorelin "from $145/mo" with no dose breakdown, and names no medical director, prescriber, or pharmacy.

EdgeRx is men's-only, names a Chief Medical Advisor and a 503A pharmacy claim, and prices NAD+ bundled with glutathione from $99/mo.

FORM lists NAD+, sermorelin, GHK-Cu cream and glutathione under Peptides/Longevity — and publishes a price for none of them.

MyDrHank NAD+ starts at $137 a month for the nasal spray and $155 for the weekly injection, with no plan length shown. Free consult, no bloodwork to start.

Pallas Health advertises NAD+ at "$189/mo average". There is no monthly plan — that figure is $567 billed every 12 weeks.

WellMedr sells NAD+, B12 and sermorelin at $99/mo. All three pages are one template with the molecule swapped — and the bill renews every 21 days.

Synergy Rx prints NAD+, sermorelin and glutathione at $275/mo on its homepage. Its Terms say the final charge may differ.

Care Bare Rx NAD+ costs $325 a month in its own catalog, not the "$199" its pages advertise. No prepay term; an $80 fee applies if nothing is prescribed.

Breeze Meds sells NAD+ at $169, $179 and $249 on the same page — and publishes no terms of service or refund policy at all.

Oak now prices NAD+ at $175 a month with the review, messaging and shipping included. Sermorelin and tesamorelin are priced after the assessment.

Sesame sells cash-pay clinician visits at about $47 to $69. No NAD+, no peptides, no longevity line — and its "anti-aging" tab is dermatology.

Found's GLP-1 plan is $199 insured or $289 cash on a monthly plan, billed every 28 days. The $99 and $169 it advertises need 12 months paid up front.

RNK Health advertises NAD+ and sermorelin from $129. That is the six-month rate; month to month is $169, and pharmacy fees can sit on top.

Luvo Health sells NAD+ and sermorelin at $199 every four weeks, all-in, after a half-price first month. Its terms name the pharmacies.

bmiMD publishes every NAD+ and sermorelin price before intake. The $119 and $99 it advertises are 12- and 6-month prepays; month to month is $159 and $139.

Eden sells NAD+, sermorelin and glutathione from $91, but every price is a first month, and a $39-then-$99 membership is required on top.

Embody sells NAD+ injections or nasal spray at a flat $99 a month with the visit included. Its FAQ and its refund policy disagree on automatic billing.

Bodybuilding Health+ sells NAD+ and sermorelin from $129 a month, names its pharmacies and doctors, and keeps its plan terms behind the intake.

Henry Meds charges $129 a month for testosterone and $149 for women's HRT, with visits, labs and medication included. What it covers, and where it falls short.

Midi Health is a virtual menopause clinic with a longevity visit. A self-pay visit is $250, then $150; HRT, labs and its compounded creams cost extra.

Joi + Blokes prints every NAD+, sermorelin, rapamycin and TRT price. The catch: a three-month minimum, no refunds, and a $99 TRT that needs a year.

Ways2Well starts with a $499 lab-and-visit plan or $125 a month, then prescribes peptides and hormones it prices only after you are in.

Bioverse sells NAD+ from $259 a month and metformin from $55 with no membership fee, but only in ten states, and every sale is final.

Maximus prices testosterone at $99.99 to $199.99 a month by plan length and states a 503A standard, but labs cost extra and long plans lock you in.

Calculate your biological age from a standard blood panel using the Levine PhenoAge equation (Levine et al., 2018).

Estimate your VO2max and a 'fitness age' from age, sex, waist, resting heart rate, and activity — using the inputs of the validated HUNT non-exercise model.

Compare biological-age and biomarker tests by price, test type and evidence, with educational guidance on what each result can and cannot tell you.

Longevity and anti-aging telehealth graded on a fixed rubric: what each clinic tests, what it costs, and what the evidence behind it actually supports.

Who writes Longevity Graded, what we review, where our facts come from, and how the site is funded.

Longevity and anti-aging telehealth providers for 2026, each graded on price transparency, clinical oversight and support from its own published terms, not on lifespan claims.

How Longevity Graded is funded, what a partner is, and where the facts in our grades and reviews come from.

Where the facts in our reviews and articles come from, how provider grades are set, how dates and corrections work, and how affiliate links are handled.

Why the longevity and anti-aging coverage here is educational reading, not medical advice, and what to run past a licensed clinician first.

What Longevity Graded does and doesn't collect: analytics on a US opt-out basis under Consent Mode v2, the choice stored in your browser, and how to reset it.

Fully-sourced research on longevity and anti-aging care. Every claim tied to peer-reviewed work, with trial findings kept separate from marketing.

Every provider we grade, with the full write-up behind the letter — filterable by NAD+ & peptides, TRT & hormones, or diagnostics & testing.

Browse every Longevity Graded review, research article, calculator, ranking and policy page.

The terms that govern your use of Longevity Graded — what our grades mean, the limits of the information we publish, and the New York law that applies.

Free longevity tools: calculate biological age with Levine PhenoAge, estimate fitness age with the HUNT model, and compare biological-age testing costs.