Research
Evidence-based research
Independent reviews from Longevity Graded — every claim tied to primary research or official labeling.
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Longevity Medicine: What's Proven vs Hyped
An honest, evidence-graded tour of the longevity toolkit — what has human outcome RCTs versus what is animal or mechanistic-only.
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Do NAD+ and Peptides Actually Extend Lifespan?
NAD+ precursors reliably raise NAD+ but show modest, mixed human outcomes. Peptides and growth hormone carry real cautions. An honest evidence review.
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Rapamycin & Metformin for Longevity: The Evidence
Strong animal data, a glaring human RCT gap. What the PEARL pilot, the TAME rationale, and metformin's observational signal really show.
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Are Longevity Clinics Worth It?
DTC and IV longevity clinics sit on the weakest evidence in the field. What a critical review found, and how to vet a provider before paying.
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Rapamycin for Longevity: Hype vs Evidence
Rapamycin is the most reproducible lifespan extender in mice — but there is no human longevity trial. An honest split of the hype from the evidence.
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What the PEARL Trial Actually Showed About Rapamycin
PEARL was the largest decentralized RCT of rapamycin in healthy aging — and it missed its primary endpoint. An honest readout of what it did and didn't prove.
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Longevity Clinics vs Lab Memberships vs Rx Telehealth: What Each Delivers
The longevity market splits into four bands: concierge clinics, membership programs, DTC labs, single-product Rx. What each delivers, and who it's for.
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Biological Age Tests: Do Epigenetic Clocks Actually Work?
Epigenetic clocks (Horvath, GrimAge, DunedinPACE) predict aging well in populations — but are noisy and unproven for individuals. An honest evidence review.
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NAD+ for Longevity: What the Trials Actually Show
NR and NMN reliably raise NAD+ in humans, but the trials mostly fail to show clinical or longevity outcomes. An honest review of the hype versus the data.
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What Do Longevity Biomarker Panels Actually Test?
Longevity panels mix genuinely useful, outcome-validated markers (ApoB, HbA1c, hs-CRP) with vanity numbers. An honest, evidence-graded breakdown.
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GLP-1s for Healthspan & Longevity: The Evidence
GLP-1 drugs have the strongest human outcome data in longevity — but it's cardiometabolic risk reduction, not proven lifespan extension. An honest review.
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Peptides for Longevity: What's Real and What's Marketing
Most longevity peptides are sold on mechanism and anecdote, not human outcomes. An honest, citation-backed review of what the evidence actually supports.
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Metformin for Longevity: The TAME Trial Evidence
Metformin's anti-aging case is mechanistic and observational — no completed RCT proves it. Why the TAME trial exists, and the exercise caveat.
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Concierge vs Membership Longevity: What You Actually Get
Concierge clinics ($8k–$25k/yr) sell diagnostics; membership programs ($99–$300/mo) sell ongoing treatment. What each delivers, and where the money goes.
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How We Grade Longevity Providers: Our Methodology
The five-axis rubric behind our longevity provider rankings: oversight, evidence honesty, transparency, price, and conflicts of interest.
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Best Longevity Supplements, Rated by Evidence (2026)
We grade the popular longevity supplements — NMN, NR, spermidine, resveratrol, CoQ10, omega-3, vitamin D, fisetin, GlyNAC — on human evidence, not hype.
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What Is a Longevity Doctor (and Do You Need One)?
A longevity doctor blends preventive medicine, biomarker testing, and lifestyle coaching. What they really do, credentials to check, and who needs one.
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Spermidine for Longevity: What the Evidence Shows
Spermidine induces autophagy and dietary intake tracks with lower mortality — but the best human trial was negative. An honest, evidence-graded review.
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The Sitting-Rising Test & Longevity: What the Evidence Actually Shows
The sitting-rising and sit-to-stand tests predict mortality in research — but they're markers of strength, balance, and flexibility, not a verdict.
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How Much Does a Longevity Clinic Cost?
Longevity care runs from ~$200/yr lab memberships to $20k+ concierge programs. A 2026 price-band guide to what each tier buys — and what's worth paying for.
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Free Biological-Age Tests & Calculators: Do They Actually Work?
Free biological-age calculators range from validated (PhenoAge from a basic blood panel) to entertainment. An honest guide to what's worth your time.
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Taurine for Longevity: Does the 2023 Science Study Hold Up?
A 2023 Science paper called taurine deficiency a driver of aging. A 2025 Science follow-up questioned its core premise. An honest, evidence-graded review.
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Urolithin A (Mitopure): Mitochondrial Hype or Real?
Urolithin A (Mitopure) has the cleanest human-trial record of any mitochondrial supplement — modest muscle gains in RCTs. But healthspan isn't lifespan.
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Fisetin as a Senolytic: What "Hit-and-Run" Dosing Shows
Fisetin was the standout senolytic flavonoid in mouse screens and extended lifespan ~10%. In humans, the longevity data are essentially zero. An honest review.
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GlyNAC (Glycine + NAC) for Aging: What the Baylor Trials Actually Show
Baylor RCTs report GlyNAC corrects glutathione deficiency and several aging hallmarks in older adults. But the trials are small and the headlines overstate it.
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Alpha-Ketoglutarate (Rejuvant/AKG): Does the "8 Years Younger" Claim Hold Up?
The viral "8 years younger" AKG result came from a 42-person study with no placebo group and an unvalidated aging clock. An honest evidence review.
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Dasatinib + Quercetin: How Far Along Is the Flagship Senolytic?
Dasatinib + quercetin is the first-in-human senolytic — with small IPF and kidney signals. But it's a chemo drug plus a flavonoid, with no longevity RCT yet.
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TruDiagnostic TruAge Review: Is the $229 Epigenetic Clock Worth It?
TruDiagnostic's TruAge uses the well-validated DunedinPACE clock — but no test proves the score predicts YOUR outcomes. An honest, evidence-graded review.
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Function Health Review: Are 100+ Biomarkers Worth $499/yr?
Function Health's 100+ lab membership surfaces real outcome-validated markers — but roughly half are basic labs, and it tests without treating. Honest review.
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Bryan Johnson's Blueprint Review: Evidence vs N-of-1 Hype
Bryan Johnson's Blueprint is a single-subject experiment with no control group — and roughly 90% of its likely benefit is replicable diet, sleep, and exercise.
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VO2 Max and Longevity: The Strongest Fitness Predictor of Lifespan
Cardiorespiratory fitness is one of the best-validated predictors of mortality — low fitness carries risk on par with smoking, and it's trainable.
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Grip Strength as a Longevity Biomarker: What the Evidence Shows
In the 140,000-person PURE study, grip strength outpredicted systolic blood pressure for mortality. A genuinely strong, free, at-home biomarker.
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Fasting-Mimicking Diet (ProLon) Review: Does the Evidence Hold Up?
ProLon's 5-day fasting-mimicking diet has real human trials behind it — but most are tied to its inventor's company. An honest, graded look.
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Hyperbaric Oxygen for Aging: Does the Telomere Claim Hold Up?
One small Israeli trial reported HBOT lengthened telomeres 38% and cut senescent cells. It's striking, unreplicated, and expensive. An honest, graded review.
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Creatine for Aging: The Cheapest Evidence-Backed Supplement?
Creatine has the strongest human evidence of any longevity supplement — for healthspan, not lifespan. With resistance training it adds muscle and strength.
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The Hallmarks of Aging, Explained (and Why They Matter)
The hallmarks of aging are the cellular processes that drive getting old. A plain-English guide to the 2013 and 2023 framework — and why each one gets targeted.
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Sulforaphane for Longevity: Promising Biology, Preclinical Proof
Sulforaphane from broccoli extends lifespan in worms and activates Nrf2 — but the human longevity evidence is preclinical. An honest, evidence-graded review.
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Glycine for Longevity: The Other Half of GlyNAC
Glycine alone extended mouse lifespan ~6% in the ITP. But the dramatic 'reverses aging' results belong to the GlyNAC combo, not solo glycine. An honest review.
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Microdose Lithium for Longevity & Brain Aging: The Evidence
A 2025 Nature study tied lithium deficiency to Alzheimer's in mice. But that's mouse healthspan, not human lifespan — and lithium has a narrow safety window.
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Ergothioneine: The "Longevity Vitamin"? An Evidence-Graded Review
Ergothioneine has a strong observational link to lower mortality — but no human trial, and the signal may just track a healthy diet. An honest grade.
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Omega-3 for Longevity: What the DO-HEALTH Trial Actually Shows
DO-HEALTH found 1 g/day omega-3 slowed epigenetic clocks by ~3–4 months. Real, randomized — but a small, surrogate effect. An honest evidence grade.
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CoQ10 & Ubiquinol for Aging: What the Evidence Actually Shows
KiSel-10 showed CoQ10 plus selenium cut cardiovascular mortality in elderly Swedes — but the benefit is CV-specific, not lifespan. An honest grade.
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Best Epigenetic Clock: GrimAge vs PhenoAge vs DunedinPACE
GrimAge predicts mortality, PhenoAge predicts disease, DunedinPACE measures pace of aging. No clock is validated to guide your treatment. An honest comparison.
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GlycanAge Review: Is the Glycan Aging Test Worth It?
GlycanAge measures IgG glycans tied to inflammation, and they move with lifestyle — but independent validation is thin and it can't localize a problem. Graded.
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Galleri Multi-Cancer Test Review: Is It Worth It?
Galleri's blood test can flag a cancer signal across many types — but no trial shows it saves lives, and false positives trigger costly cascades. Graded.
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Fountain Life vs Human Longevity Inc: MRI Clinics Compared
Two whole-body-MRI longevity clinics compared. The headline isn't the price — it's the incidentaloma problem: most scary scan findings turn out to be nothing.
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Sauna & Longevity: What the Finnish Studies Actually Show
Frequent sauna use is tied to ~40% lower all-cause mortality in Finnish men — but it's one observational cohort, not a randomized trial. An honest grade-B read.
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Cold Plunge for Longevity: Hype vs Evidence
Cold exposure extends lifespan in worms and flies — but there's zero human lifespan data, and the human evidence is about recovery and mood, not living longer.
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Zone 2 Training for Longevity: The Evidence, Graded Honestly
Zone 2 has a strong mitochondrial mechanism and builds the fitness that predicts lifespan — but no trial proves Zone 2 itself extends life. Graded honestly.
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Outlive by Peter Attia: An Evidence-Based Review
Attia's Outlive popularized Medicine 3.0 and the Four Horsemen. We grade the framework honestly: where the evidence is strong, and where it's reasoned opinion.
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Best Longevity Blood Test Services, Compared (2026)
Function, InsideTracker, Lifeforce, Superpower — graded honestly. The four cheap outcome-validated markers matter; the '100+ biomarker' count mostly doesn't.
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Best At-Home Biological Age Test (2026): Honestly Graded
Blood-methylation clocks are the only defensible at-home bio-age tier; saliva and telomere kits are noisier. None proves you're aging slower. Honestly graded.
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InsideTracker Review: Worth It in 2026?
InsideTracker adds DNA and an 'InnerAge' score to blood panels. The core markers are real, but it's pricier per marker and recommendations skew to upsells.
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Lifeforce Review: Is the Membership Worth It?
Lifeforce bundles a clinician and Rx onto a ~50-marker quarterly panel for ~$129/mo. That crosses test-into-treat — but the panel is narrow and the upsell real.
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Does Resveratrol Actually Work for Longevity?
A skeptical, evidence-graded review: the SIRT1 story was an artifact, a 2025 primate trial found no lifespan benefit, and oral resveratrol barely reaches cells.
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Collagen for Aging: What the Evidence Says
Industry-funded trials show skin and joint benefits; independent reviews are cautious. Collagen digests to amino acids, and the longevity claim is unproven.
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Quercetin for Longevity: Senolytic Hype vs Evidence
Quercetin's senolytic effect needs the dasatinib combination. Standalone quercetin has no human senolytic evidence — just modest anti-inflammatory effects.
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Superpower Health Review: Is the $499 100-Lab Membership Worth It?
Superpower's $499/yr 100+ lab membership is slick and cheap-per-marker — but it tests without treating, and the panel leans on padding. Honest, graded review.
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Function Health vs Superpower: Which Lab Membership Wins?
Function Health vs Superpower, graded honestly: nearly identical 100+ lab memberships that both test without treating. The tiebreaker isn't the marker count.
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NOVOS Core Review: Does the 12-Ingredient Longevity Drink Work?
NOVOS Core bundles 12 longevity ingredients into one daily drink. The formulation logic is real; the human lifespan proof isn't. An honest, graded review.
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Tally Health Review: Is the TruAge Epigenetic Membership Worth It?
Tally Health pairs a TruAge epigenetic-age test with coaching and a supplement. The clock is real science; tracking your own aging with it isn't proven.
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NOVOS vs Tally Health: Which Longevity Brand Is Worth It?
NOVOS sells a multi-pathway longevity supplement; Tally Health sells an epigenetic-age test plus its own pill. A graded, honest head-to-head on what's proven.
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Spermidine vs Fisetin: Two Longevity Supplements, Honestly Compared
Spermidine targets autophagy; fisetin clears senescent cells. Different mechanisms, different evidence grades — an honest, head-to-head longevity comparison.
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Function Health vs InsideTracker: Which Lab-Test Membership Wins?
Function casts a wide 100+ marker net; InsideTracker pairs fewer markers with an algorithm. We grade breadth, actionability, price — and who each fits.
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Glycine vs GlyNAC: Is Adding NAC Worth It for Longevity?
GlyNAC adds N-acetylcysteine to glycine for glutathione restoration. Is the extra ingredient worth it for longevity? An honest, graded comparison.
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Acarbose for Longevity: The Strongest Mouse Drug You've Never Heard Of
Acarbose robustly extended mouse lifespan in the NIA's rigorous ITP — better replicated than most longevity drugs. But there are zero human longevity trials.
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Intermittent Fasting for Longevity: What the Human Trials Actually Show
Time-restricted eating and 5:2 have strong animal data — but human trials show the benefit is mostly about eating less, not the clock. No lifespan proof.
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Berberine for Longevity: Nature's Metformin, or Marketing?
Berberine activates AMPK like metformin and lowers glucose and lipids in humans — but its longevity evidence is animal-only. An honest look at the hype.
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