Research
Evidence-based research
Every claim on Longevity Graded is tied to primary research or official labeling. Each row below shows how many primary sources the piece cites, and whether it puts an explicit evidence tier on the compounds it covers rather than leaving the verdict in the prose.
Featured partner · Grade B
CoreAge Rx
Clinician-reviewed NAD+ and sermorelin with published starting prices and human support. Confirm the full cost and renewal terms before paying.
Advertising disclosure. We may earn a commission if you start through this link, at no extra cost to you. Judge every provider on the marks we print beside it. See our disclosure.
Filter by subject
Clinics & testing
Are Longevity Clinics Worth It?
DTC and IV longevity clinics sit on the weakest evidence in the field. What a critical review found, and how to vet a provider before paying.
2 sourcesUpdated Jul 2026
Longevity Clinics vs Lab Memberships vs Rx Telehealth: What Each Delivers
The longevity market splits into four bands: concierge clinics, membership programs, DTC labs, single-product Rx. What each delivers, and who it's for.
7 sourcesUpdated Oct 2026
Do Biological Age Tests Actually Work? An Evidence Review
Epigenetic clocks (Horvath, GrimAge, DunedinPACE) predict aging well in populations — but are noisy and unproven for individuals. An honest evidence review.
11 sourcesGraded evidence tiersUpdated Jul 2026
What Do Longevity Biomarker Panels Actually Test?
Longevity panels mix genuinely useful, outcome-validated markers (ApoB, HbA1c, hs-CRP) with vanity numbers. An honest, evidence-graded breakdown.
13 sourcesGraded evidence tiersUpdated Jul 2026
Concierge vs Membership Longevity: What You Actually Get
Concierge clinics ($8k–$25k/yr) sell diagnostics; membership programs ($99–$300/mo) sell ongoing treatment. What each delivers, and where the money goes.
4 sourcesUpdated Oct 2026
How We Grade Longevity Providers: Our Methodology
The five-factor, 14-point rubric behind every letter grade: price transparency, longevity line, oversight, pharmacy identification, and support.
6 sourcesUpdated Oct 2026
Longevity Doctor: What They Do, What They Cost, How to Vet One
A longevity doctor blends preventive medicine, biomarker testing, and lifestyle coaching. What they really do, credentials to check, and who needs one.
12 sourcesUpdated Oct 2026
How Much Does a Longevity Clinic Cost?
Compare longevity care costs: annual lab memberships, recurring clinical care, prescriptions and imaging. Check the first charge, renewal and exclusions.
8 sourcesUpdated Oct 2026
Free Biological-Age Tests & Calculators: Do They Actually Work?
Free biological-age calculators range from validated (PhenoAge from a basic blood panel) to entertainment. An honest guide to what's worth your time.
12 sourcesGraded evidence tiersUpdated Jun 2026
Best Epigenetic Clock: GrimAge vs PhenoAge vs DunedinPACE
GrimAge predicts mortality, PhenoAge predicts disease, DunedinPACE measures pace of aging. No clock is validated to guide your treatment. An honest comparison.
11 sourcesGraded evidence tiersUpdated Jun 2026
Fountain Life vs Human Longevity: Cost, Care and Screening
Compare Fountain Life and Human Longevity prices, care and follow-up. Understand why disease detection is different from a proven screening benefit.
15 sourcesGraded evidence tiersUpdated Oct 2026
Best Longevity Blood Test Services, Compared (2026)
Function, InsideTracker, Lifeforce, Superpower — graded honestly. The four cheap outcome-validated markers matter; the '100+ biomarker' count mostly doesn't.
6 sourcesUpdated Oct 2026
Best Biological Age Test (2026): At-Home Kits, Honestly Graded
Blood-methylation clocks are the only defensible at-home bio-age tier; saliva and telomere kits are noisier. None proves you're aging slower. Honestly graded.
9 sourcesGraded evidence tiersUpdated Jun 2026
Function Health vs Superpower: Which Lab Membership Wins?
Function Health vs Superpower, graded honestly: nearly identical 100+ lab memberships that both test without treating. The tiebreaker isn't the marker count.
6 sourcesGraded evidence tiersUpdated Oct 2026
NOVOS vs Tally Health: Which Longevity Brand Is Worth It?
NOVOS sells a multi-pathway longevity supplement; Tally Health sells an epigenetic-age test plus its own pill. A graded, honest head-to-head on what's proven.
6 sourcesGraded evidence tiersUpdated Oct 2026
Spermidine vs Fisetin: Two Longevity Supplements, Honestly Compared
Spermidine targets autophagy; fisetin clears senescent cells. Different mechanisms, different evidence grades — an honest, head-to-head longevity comparison.
6 sourcesUpdated Jun 2026
Function Health vs InsideTracker: Which Lab-Test Membership Wins?
Function casts a wide 160+ marker net; InsideTracker pairs fewer markers with an algorithm. We grade breadth, actionability, price — and who each fits.
7 sourcesUpdated Oct 2026
Glycine vs GlyNAC: Is Adding NAC Worth It for Longevity?
GlyNAC adds N-acetylcysteine to glycine for glutathione restoration. Is the extra ingredient worth it for longevity? An honest, graded comparison.
10 sourcesGraded evidence tiersUpdated Jun 2026
NAD+ Injections vs IV vs Oral: Which Route Has the Evidence?
Compare NAD+ injections, IV infusions and oral precursors: human evidence, route-specific limits and the costs to check before choosing.
6 sourcesUpdated Oct 2026
NMN vs NR: Which NAD+ Precursor Has the Better Evidence?
NMN and NR have been compared in a human trial. See what blood NAD+ results, clinical studies and safety data do—and do not—show about longevity.
12 sourcesUpdated Oct 2026
Prescription protocols
Do NAD+ and Peptides Actually Extend Lifespan?
NAD+ precursors reliably raise NAD+ but show modest, mixed human outcomes. Peptides and growth hormone carry real cautions. An honest evidence review.
7 sourcesGraded evidence tiersUpdated Jul 2026
Rapamycin & Metformin for Longevity: The Evidence
Strong animal data, a glaring human RCT gap. What the PEARL pilot, the TAME rationale, and metformin's observational signal really show.
5 sourcesUpdated Jun 2026
Rapamycin for Longevity: Hype vs Evidence
Rapamycin is the most reproducible lifespan extender in mice — but there is no human longevity trial. An honest split of the hype from the evidence.
11 sourcesUpdated Jul 2026
What the PEARL Trial Actually Showed About Rapamycin
PEARL was the largest decentralized RCT of rapamycin in healthy aging — and it missed its primary endpoint. An honest readout of what it did and didn't prove.
7 sourcesGraded evidence tiersUpdated Jul 2026
NAD+ for Longevity: What the Trials Actually Show
NR and NMN reliably raise NAD+ in humans, but the trials mostly fail to show clinical or longevity outcomes. An honest review of the hype versus the data.
15 sourcesUpdated Jul 2026
GLP-1s for Healthspan & Longevity: The Evidence
GLP-1 drugs have the strongest human outcome data in longevity — but it's cardiometabolic risk reduction, not proven lifespan extension. An honest review.
9 sourcesUpdated Oct 2026
Peptides for Longevity: What's Real and What's Marketing
Most longevity peptides are sold on mechanism and anecdote, not human outcomes. An honest, citation-backed review of what the evidence actually supports.
14 sourcesGraded evidence tiersUpdated Jul 2026
Metformin for Longevity: The TAME Trial Evidence
Metformin's anti-aging case is mechanistic and observational — no completed RCT proves it. Why the TAME trial exists, and the exercise caveat.
7 sourcesUpdated Oct 2026
Hyperbaric Oxygen for Aging: Does the Telomere Claim Hold Up?
One small Israeli trial reported HBOT lengthened telomeres 38% and cut senescent cells. It's striking, unreplicated, and expensive. An honest, graded review.
5 sourcesGraded evidence tiersUpdated Jun 2026
Microdose Lithium for Longevity & Brain Aging: The Evidence
A 2025 Nature study tied lithium deficiency to Alzheimer's in mice. But that's mouse healthspan, not human lifespan — and lithium has a narrow safety window.
9 sourcesGraded evidence tiersUpdated Jun 2026
Acarbose for Longevity: The Strongest Mouse Drug You've Never Heard Of
Acarbose robustly extended mouse lifespan in the NIA's rigorous ITP — better replicated than most longevity drugs. But there are zero human longevity trials.
5 sourcesGraded evidence tiersUpdated Jul 2026
TRT and Longevity: What the Trials Actually Show
Testosterone therapy is a treatment for diagnosed hypogonadism. No trial shows it extends life. Here is what TRAVERSE, the T-Trials and the guidelines found.
8 sourcesGraded evidence tiersUpdated Aug 2026
Sermorelin for Longevity: Cost, Evidence and What It Cannot Do
Sermorelin prices depend on the plan and supply period. Compare published costs, growth-hormone research and the limits of its anti-aging claims.
7 sourcesGraded evidence tiersUpdated Oct 2026
HRT, Menopause and Longevity: What the Trials Actually Show
Hormone therapy treats menopausal symptoms and protects bone. Over 18 years of follow-up it did not change all-cause mortality. Timing changes the risk picture.
4 sourcesGraded evidence tiersUpdated Aug 2026
Plasma Exchange for Longevity: What the Human Trial Shows
A human plasma-exchange trial changed biological-age markers. We examine its design, IVIG, safety and why clock changes do not prove longer life.
8 sourcesGraded evidence tiersUpdated Oct 2026
Sermorelin: What It Is, Cost, Safety and Where to Get It (2026)
Sermorelin is a compounded peptide that makes your pituitary release growth hormone. Its FDA status, what studies show and what it costs at graded providers.
6 sourcesGraded evidence tiersUpdated Oct 2026
NAD+ Therapy: Injections, IV, Cost and Evidence (2026)
NAD+ injections run about $99 to $325 a month at the providers we grade. None is FDA-approved, and no outcome trial has tested injected or IV NAD+ for aging.
7 sourcesGraded evidence tiersUpdated Oct 2026
NAD+ Injections: Benefits, Side Effects, Dosage and Cost (2026)
NAD+ injections cost about $99–$299 a month through telehealth. They are compounded, not FDA-approved, and no human trial has tested them for aging.
10 sourcesUpdated Oct 2026
Is NAD+ IV Therapy Safe? Cost, Evidence and What the Bronx Case Does and Doesn't Show
NAD+ IV drips commonly cause nausea and chest pressure if run fast, cost $299–$1,000 a session, and have no outcomes trial. Who places the line matters most.
8 sourcesUpdated Oct 2026
Sermorelin Before and After: A Realistic Results Timeline and Dosage
What sermorelin trials measured week by week: growth hormone rises within minutes, IGF-1 within two weeks, and body changes were small and mostly seen in men.
8 sourcesUpdated Oct 2026
Sermorelin Side Effects: Is Sermorelin Safe?
Sermorelin's most common side effect is injection-site pain or redness, about 16% in pediatric trials. Other effects, who should avoid it, and cancer risk.
8 sourcesUpdated Oct 2026
Supplements
Best Longevity Supplements, Rated by Evidence (2026)
We grade the popular longevity supplements — NMN, NR, spermidine, resveratrol, CoQ10, omega-3, vitamin D, fisetin, GlyNAC — on human evidence, not hype.
17 sourcesGraded evidence tiersUpdated Oct 2026
Spermidine for Longevity: What the Evidence Shows
Spermidine induces autophagy and dietary intake tracks with lower mortality — but the best human trial was negative. An honest, evidence-graded review.
10 sourcesUpdated Jun 2026
Taurine for Longevity: Does the 2023 Science Study Hold Up?
A 2023 Science paper called taurine deficiency a driver of aging. A 2025 Science follow-up questioned its core premise. An honest, evidence-graded review.
9 sourcesGraded evidence tiersUpdated Jun 2026
Urolithin A (Mitopure): Mitochondrial Hype or Real?
Urolithin A (Mitopure) has the cleanest human-trial record of any mitochondrial supplement — modest muscle gains in RCTs. But healthspan isn't lifespan.
7 sourcesGraded evidence tiersUpdated Jun 2026
GlyNAC (Glycine + NAC) for Aging: What the Baylor Trials Actually Show
Baylor RCTs report GlyNAC corrects glutathione deficiency and several aging hallmarks in older adults. But the trials are small and the headlines overstate it.
7 sourcesGraded evidence tiersUpdated Jul 2026
Alpha-Ketoglutarate (Rejuvant/AKG): Does the "8 Years Younger" Claim Hold Up?
The viral "8 years younger" AKG result came from a 42-person study with no placebo group and an unvalidated aging clock. An honest evidence review.
5 sourcesGraded evidence tiersUpdated Jun 2026
Creatine for Aging: The Cheapest Evidence-Backed Supplement?
Creatine has the strongest human evidence of any longevity supplement — for healthspan, not lifespan. With resistance training it adds muscle and strength.
10 sourcesGraded evidence tiersUpdated Jun 2026
Sulforaphane for Longevity: Promising Biology, Preclinical Proof
Sulforaphane from broccoli extends lifespan in worms and activates Nrf2 — but the human longevity evidence is preclinical. An honest, evidence-graded review.
9 sourcesGraded evidence tiersUpdated Jun 2026
Glycine for Longevity: The Other Half of GlyNAC
Glycine alone extended mouse lifespan ~6% in the ITP. But the dramatic 'reverses aging' results belong to the GlyNAC combo, not solo glycine. An honest review.
8 sourcesGraded evidence tiersUpdated Jun 2026
Ergothioneine: The "Longevity Vitamin"? An Evidence-Graded Review
Ergothioneine has a strong observational link to lower mortality — but no human trial, and the signal may just track a healthy diet. An honest grade.
10 sourcesGraded evidence tiersUpdated Jun 2026
Omega-3 for Longevity: What the DO-HEALTH Trial Actually Shows
DO-HEALTH found 1 g/day omega-3 slowed epigenetic clocks by ~3–4 months. Real, randomized — but a small, surrogate effect. An honest evidence grade.
7 sourcesGraded evidence tiersUpdated Jun 2026
CoQ10 & Ubiquinol for Aging: What the Evidence Actually Shows
KiSel-10 showed CoQ10 plus selenium cut cardiovascular mortality in elderly Swedes — but the benefit is CV-specific, not lifespan. An honest grade.
9 sourcesGraded evidence tiersUpdated Jun 2026
Does Resveratrol Actually Work for Longevity?
A skeptical, evidence-graded review: the SIRT1 story was an artifact, a 2025 primate trial found no lifespan benefit, and oral resveratrol barely reaches cells.
10 sourcesGraded evidence tiersUpdated Jul 2026
Collagen for Aging: What the Evidence Says
Industry-funded trials show skin and joint benefits; independent reviews are cautious. Collagen digests to amino acids, and the longevity claim is unproven.
10 sourcesGraded evidence tiersUpdated Jun 2026
Quercetin for Longevity: Senolytic Hype vs Evidence
Quercetin's senolytic effect needs the dasatinib combination. Standalone quercetin has no human senolytic evidence — just modest anti-inflammatory effects.
10 sourcesGraded evidence tiersUpdated Jun 2026
NOVOS Core Clinical Trial: What STAMINA Actually Shows
STAMINA found favorable vascular markers after six months of NOVOS Core. Examine the published trial, incomplete follow-up and limits of its longevity claims.
4 sourcesGraded evidence tiersUpdated Oct 2026
Berberine for Longevity: Nature's Metformin, or Marketing?
Berberine activates AMPK like metformin and lowers glucose and lipids in humans — but its longevity evidence is animal-only. An honest look at the hype.
11 sourcesGraded evidence tiersUpdated Oct 2026
Senolytics
Fisetin as a Senolytic: What "Hit-and-Run" Dosing Shows
Fisetin was the standout senolytic flavonoid in mouse screens and extended lifespan ~10%. In humans, the longevity data are essentially zero. An honest review.
8 sourcesGraded evidence tiersUpdated Jun 2026
Dasatinib + Quercetin: How Far Along Is the Flagship Senolytic?
Dasatinib + quercetin is the first-in-human senolytic — with small IPF and kidney signals. But it's a chemo drug plus a flavonoid, with no longevity RCT yet.
8 sourcesGraded evidence tiersUpdated Jun 2026
Training, diet & lifestyle
The Sitting-Rising Test & Longevity: What the Evidence Actually Shows
The sitting-rising and sit-to-stand tests predict mortality in research — but they're markers of strength, balance, and flexibility, not a verdict.
9 sourcesUpdated Jul 2026
VO2 Max by Age: Norms, and Why It Predicts Lifespan
Median VO2 max by age and sex from 16,278 lab treadmill tests, what counts as good for your age, and why low fitness carries risk on par with smoking.
8 sourcesGraded evidence tiersUpdated Oct 2026
Grip Strength as a Longevity Biomarker: What the Evidence Shows
In the 140,000-person PURE study, grip strength outpredicted systolic blood pressure for mortality. A genuinely strong, free, at-home biomarker.
8 sourcesGraded evidence tiersUpdated Jun 2026
Fasting-Mimicking Diet (ProLon) Review: Does the Evidence Hold Up?
ProLon's 5-day fasting-mimicking diet has real human trials behind it — but most are tied to its inventor's company. An honest, graded look.
7 sourcesGraded evidence tiersUpdated Jul 2026
Sauna & Longevity: What the Finnish Studies Actually Show
Frequent sauna use is tied to ~40% lower all-cause mortality in Finnish men — but it's one observational cohort, not a randomized trial. An honest grade-B read.
8 sourcesGraded evidence tiersUpdated Jun 2026
Cold Plunge for Longevity: Hype vs Evidence
Cold exposure extends lifespan in worms and flies — but there's zero human lifespan data, and the human evidence is about recovery and mood, not living longer.
8 sourcesGraded evidence tiersUpdated Jun 2026
Zone 2 Training for Longevity: The Evidence, Graded Honestly
Zone 2 has a strong mitochondrial mechanism and builds the fitness that predicts lifespan — but no trial proves Zone 2 itself extends life. Graded honestly.
12 sourcesGraded evidence tiersUpdated Oct 2026
Intermittent Fasting for Longevity: What the Human Trials Actually Show
Time-restricted eating and 5:2 have strong animal data — but human trials show the benefit is mostly about eating less, not the clock. No lifespan proof.
6 sourcesGraded evidence tiersUpdated Jul 2026
The science of aging
Longevity Medicine: What's Proven vs Hyped
An honest, evidence-graded tour of the longevity toolkit — what has human outcome RCTs versus what is animal or mechanistic-only.
20 sourcesGraded evidence tiersUpdated Oct 2026
The Hallmarks of Aging, Explained (and Why They Matter)
The hallmarks of aging are the cellular processes that drive getting old. A plain-English guide to the 2013 and 2023 framework — and why each one gets targeted.
8 sourcesUpdated Jul 2026
Glutathione Injections: Benefits, Side Effects and the August 2026 FDA Alert
FDA linked 30+ IV glutathione reactions to a supplement-grade ingredient. What the injections do, what the evidence shows, and what to ask a provider.
10 sourcesUpdated Oct 2026