The science of aging
Sermorelin: What It Is, Cost, Safety and Where to Get It (2026)
Sermorelin is a compounded peptide that makes your pituitary release growth hormone. Its FDA status, what studies show and what it costs at graded providers.
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What is sermorelin?
Sermorelin is a lab-made copy of the first 29 amino acids of growth-hormone-releasing hormone. Injected under the skin, usually at bedtime, it prompts your own pituitary gland to release growth hormone instead of supplying the hormone directly. Telehealth clinics prescribe it as a compounded drug for sleep, recovery and body composition, at roughly $99 to $349 a month across the providers we grade.
Sermorelin at a glance
The short answer
- What it is: a growth-hormone-releasing peptide that makes your own pituitary release growth hormone
- FDA status: compounded, not FDA-approved; the branded version was discontinued in 2008
- What it does: reliably raises growth hormone; effects on muscle and strength are small
- What it costs: about $99 to $349 a month at the providers we grade
Is sermorelin FDA-approved?
Not in any form you can buy today. FDA approved a branded sermorelin injection, Geref, in 1997 to treat growth hormone deficiency in children with growth failure. Its maker stopped selling it in 2008, and FDA later determined it was not withdrawn for reasons of safety or effectiveness1.
What telehealth sells now is compounded sermorelin. FDA states that compounded drugs are not FDA-approved and that it does not verify their safety, effectiveness or quality before they are marketed2. No version of sermorelin has ever been approved for anti-aging.
What does the evidence show?
| Question | What the studies found | Go deeper |
|---|---|---|
| Does it raise growth hormone? | Yes. Nightly injections raised overnight growth hormone in older adults34 | Sermorelin for longevity |
| Does it build muscle or strength? | Small and uneven. A 16-week trial of a close analog raised lean mass in men only4; a 6-week trial improved two of six strength tests with no change in body composition3 | Before and after |
| What are the risks? | Giving growth hormone itself to healthy older adults brought more swelling, joint pain and carpal tunnel syndrome5 | Side effects |
| Does it slow aging? | Untested. In animals, lower growth-hormone signaling goes with longer life6 | Peptides for longevity |
How strong is the evidence?
- ARaising your own growth hormoneStrong evidence
Shown with nightly injections in older adults
- CLean mass and strengthWeak evidence
Small, uneven gains in short trials
- CSleep and well-beingWeak evidence
Well-being up in men only; sleep unchanged
- DSlowing agingInsufficient
Never tested in people
What does sermorelin cost?
Grouped by the lowest monthly figure each provider prints on its own site. This is a price list, not a ranking: each provider's grade and fine print are in its review.
| Lowest published price | Providers |
|---|---|
| Under $150 | CoreAge Rx $99 (12-month plan rate) · WellMedr from $99 (renews every 21 days) · Strut Health $99 lozenges, from $119 injection · bmiMD $139 month to month |
| $150–$199 | RNK Health $169 · Try Ageless $176 · Gala Health $199 per 28 days · Luvo Health $199 per four weeks |
| $200–$249 | Peter MD $211.65 for four weeks · He & She MD $229 |
| $250 and up | Synergy Rx $275 · Care Bare Rx $300 · CeliaRx $349 per fill |
Some providers print only a first-month or "from" figure: Telos Rx, Eden, System Labs, Wellorithm, MyDrHank and Bodybuilding Health+. Oak quotes sermorelin after its assessment, and Breeze Meds shows two different figures. The full side-by-side is on the graded board.
How do you choose a sermorelin provider?
- Know the term. A 12-month plan rate, a 28-day cycle and a first-month price can all look like "per month."
- Check what the price includes. The clinician visit, syringes and shipping are inside some figures and billed on top of others.
- Ask who makes it. Look for a named dispensing pharmacy and a stated 503A standard.
- Ask about labs. Find out whether a baseline IGF-1 test is part of the intake.
- Read the cancel terms before the first renewal, not after.
- Pick the form on purpose. The trials above used injections. Tablets, lozenges and sprays have less behind them.
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Frequently asked questions
What is sermorelin used for?
Telehealth clinics prescribe it for sleep, recovery and body composition in adults who want higher growth hormone. Its only FDA approval, under the brand Geref, was for growth hormone deficiency in children with growth failure, and that product was discontinued in 2008. It has never been approved for anti-aging.
How much does sermorelin cost?
Across the providers we grade, the lowest published monthly figures run from about $99 to $349. Many of the low numbers are a 12-month plan rate, a first-month price or a 21- or 28-day cycle, so check the term before you compare. The month-to-month price is usually higher than the headline.
Is sermorelin safe?
Short trials in older adults reported few side effects; one 16-week trial noted only a temporary rise in blood lipids. The bigger question is growth hormone itself: giving it to healthy older adults brought more swelling, joint pain and carpal tunnel syndrome in the standing systematic review. Compounded sermorelin is not checked by FDA for quality before it is sold, so the pharmacy that makes it matters.
Is sermorelin the same as HGH?
No. HGH is the growth hormone itself. Sermorelin is a signal that tells your pituitary to release its own growth hormone, so the body's normal feedback limits stay in place. That is a reasonable safety argument for sermorelin, but it does not show that raising growth hormone helps healthy adults age better.
How long does sermorelin take to work?
Growth hormone rises within minutes of an injection, and IGF-1 rose within about two weeks in a 16-week trial. Changes you could notice, such as lean mass, were small and showed up in men but not women over four months. Our before-and-after guide covers what to expect.
References
- U.S. Food and Drug Administration (2013). Determination That GEREF (Sermorelin Acetate) Injection, 0.5 Milligrams Base/Vial and 1.0 Milligrams Base/Vial, and GEREF (Sermorelin Acetate) Injection, 0.05 Milligrams Base/Amp, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness. Federal Register, 78 FR 14095.
- U.S. Food and Drug Administration (2025). Compounding and the FDA: Questions and Answers. FDA — Human Drug Compounding.
- Vittone J, Blackman MR, Busby-Whitehead J, et al. (1997). Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.. Metabolism.
- Khorram O, Laughlin GA, Yen SS (1997). Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women.. Journal of Clinical Endocrinology & Metabolism.
- Liu H, Bravata DM, Olkin I, et al. (2007). Systematic review: the safety and efficacy of growth hormone in the healthy elderly.. Annals of Internal Medicine.
- Bartke A (2019). Growth Hormone and Aging: Updated Review.. The World Journal of Men's Health.
Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.
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