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NAD+ Therapy: Injections, IV, Cost and Evidence (2026)

NAD+ injections run about $99 to $325 a month at the providers we grade. None is FDA-approved, and no outcome trial has tested injected or IV NAD+ for aging.

Researched & graded by Tom Vance · Lead Reviews Analyst
Updated
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Evidence graded in this piece

  • A1strong
  • B0mixed
  • C3thin
How we grade
A

Featured partner

Grade A

CoreAge Rx

Doctor-reviewed longevity peptides and NAD+ with one published per-protocol price and built-in human support.

$93–$99/mo (12-mo plan)

We may earn a commission through this link, at no extra cost to you.

Check availability
Pricing
Flat monthly, no membership
Pharmacy
503A compounding pharmacy
Labs
No labs required
Consult
Clinician review included
Support
1:1 nurse + dietitian

Grades come from each provider's published terms. How we're funded

C

Partner

Grade C

Wellorithm

The sermorelin and NAD+ pages exist and carry a price — they are also unlinked, unlisted, and printed with somebody else's copy on them.

$150 first mo, then $200/mo*

We may earn a commission through this link, at no extra cost to you.

Visit Wellorithm

The "$200/mo*" carries an asterisk that page does not resolve; the footnote Wellorithm publishes with that same figure elsewhere conditions it on a "3-month plan paid upfront" and adds that "Actual price will depend on product and plan prescribed". Compounded and not FDA-approved. Graded on the same rubric as every other provider on our scorecard.

What is NAD+ therapy?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme every cell uses to make energy and repair DNA, and its levels fall with age1. "NAD+ therapy" means taking NAD+ itself by injection, IV drip or nasal spray, or raising it with oral precursors such as NR and NMN. At the providers we grade, at-home injections run about $99 to $325 a month. The routes that cost the most have the least evidence.

NAD+ at a glance

The short answer

  • What it is: a coenzyme your cells use for energy and DNA repair; levels fall with age
  • FDA status: no NAD+ product is FDA-approved; what clinics sell is compounded
  • What it does: oral NR and NMN raise NAD+; injected and IV NAD+ have no outcome trial
  • What it costs: about $99 to $325 a month for at-home injections

Is NAD+ FDA-approved?

No. FDA's drug-approval database lists no approved NAD+ product for any use. The injections, nasal sprays and IV bags clinics prescribe are compounded, and FDA states that compounded drugs are not FDA-approved and that it does not verify their safety, effectiveness or quality before they are marketed2. Oral NR and NMN are sold as supplements, not prescription drugs.

What does the evidence show?

Do oral NR or NMN raise NAD+?Yes, reliably, and they were well tolerated3NMN vs NR
Do they make you stronger or fitter?Mostly no. A 2025 meta-analysis found no gain in muscle mass or function in older adults4; a 28-day NMN trial moved weight and cholesterol but not strength or stamina5NAD+ for longevity
Do injections or IV drips work?Untested. A 2026 review of 113 studies found no outcome trial of IV or intramuscular NAD+ for anti-aging or wellness6Injections vs IV vs oral
What happens during an IV drip?In the one infusion study, blood NAD+ did not rise for the first two hours of a six-hour drip7Is NAD+ IV therapy safe?
Does it slow aging?Inconclusive for every route6Do NAD+ and peptides work?

How strong is the evidence?

  1. A
    Oral NR or NMN raising NAD+Strong evidence

    Reliable and well tolerated

  2. C
    Oral NR or NMN improving strength or fitnessWeak evidence

    Mostly null; small metabolic shifts

  3. D
    Injected or IV NAD+, any outcomeInsufficient

    No outcome trial

  4. D
    Any route slowing agingInsufficient

    Inconclusive

The routes sold as the serious option are the ones nobody has tested for results.

What do NAD+ injections cost?

Grouped by the lowest month-to-month injection price each provider prints on its own site. This is a price list, not a ranking: each provider's grade and fine print are in its review.

Injection price per monthProviders
Under $150CoreAge Rx $93 (12-month plan rate) · Embody $99
$150–$199bmiMD $159 · HealthRX $161 · RNK Health $169 · Breeze Meds $169 · yourEra from $170 · Oak $175 · Enhance MD $199 · Gala Health $199 per 28 days · Luvo Health $199 per four weeks
$200–$249He & She MD $229 · Direct Meds $249 · RxSpan MD $249 · Sprout Health $249 · Try Ageless $249
$250 and upSynergy Rx $275 · Care Bare Rx $325

Others sell NAD+ as a block, a prepaid plan or a first month: Peter MD ($369 for eight to ten weeks), CeliaRx ($399 per fill), MadeMed and Pallas Health (prepaid plans), and Eden and System Labs (first-month prices). Nasal sprays and tablets are often cheaper; the full side-by-side is on the graded board, and the full cost breakdown is in NAD+ injections: benefits, side effects and cost.

How do you choose an NAD+ provider?

  • Know the term. A 12-month plan rate, a 28-day cycle and a first-month price can all look like "per month."
  • Check the dose behind the price. Some providers charge more for 1,000 mg than for 500 mg; others charge one price at every dose.
  • Ask who makes it. Look for a named dispensing pharmacy and a stated 503A standard.
  • For an IV drip, check the clinic. Ask who places the line and whether a licensed clinician supervises.
  • Read the cancel terms before the first renewal, not after.
  • Decide what you are paying for. Injections and IV buy absorption and convenience, not a proven result.

Read next

Frequently asked questions

What does NAD+ do in the body?

NAD+ is a coenzyme your cells use to turn food into energy and to run repair enzymes, including the sirtuins and the enzymes that fix damaged DNA. Levels decline with age, which is why it is marketed for longevity. Raising it reliably is easy; showing that raising it improves health in people is the part the trials have not done.

How much do NAD+ injections cost?

At the providers we grade, at-home NAD+ injections run from about $99 to $325 a month on the lowest published price. Many headline figures are a 12-month plan rate, a 28-day cycle or a first month, so the month-to-month price is often higher than the number on the homepage. IV drips at a clinic are usually priced per session.

Are NAD+ injections better than NR or NMN pills?

No trial answers that. Injections skip the digestive breakdown that limits swallowed NAD+, but a 2026 review of 113 studies found no outcome trial of IV or intramuscular NAD+ for anti-aging or wellness. The pills are the only route with randomized human trials, and those mostly show NAD+ going up without strength or fitness following.

Is NAD+ FDA-approved?

No. No NAD+ product appears as an approved drug in FDA's database. The NAD+ injections, nasal sprays and IV bags that clinics prescribe are compounded, and FDA does not check compounded drugs for safety, effectiveness or quality before they are sold. That is why it is worth asking which pharmacy makes yours.

How long does an NAD+ IV drip take?

Several hours. In the one published infusion study, a six-hour drip was used and blood NAD+ did not rise at all for the first two hours, because the body cleared it as fast as it went in. Our guide to IV safety covers what to check before you book a clinic.

References

  1. Imai S, Guarente L (2014). NAD+ and sirtuins in aging and disease.. Trends in Cell Biology.
  2. U.S. Food and Drug Administration (2025). Compounding and the FDA: Questions and Answers. FDA — Human Drug Compounding.
  3. Martens CR, Denman BA, Mazzo MR, et al. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications.
  4. Prokopidis K, Moriarty F, Bahat G, et al. (2025). The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis. Journal of Cachexia, Sarcopenia and Muscle.
  5. Pencina KM, Valderrabano R, Wipper B, et al. (2023). Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.. Journal of Clinical Endocrinology & Metabolism.
  6. Gallagher C, Emmanuel OO (2026). NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence. Ageing Research Reviews.
  7. Grant R, Berg J, Mestayer R, et al. (2019). A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD.. Frontiers in Aging Neuroscience.

Medical disclaimer: This content is for general educational purposes only and is not medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting, stopping, or changing any treatment.

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