PhenoAge (phenotypic age) is a published measure of biological age developed by Morgan Levine and colleagues in 2018. It combines nine routine clinical blood biomarkers and your chronological age into a single 'age-equivalent' number, trained on NHANES mortality data. The estimate reflects the model's age-equivalent risk pattern; it is not a measurement of your actual lifespan.

Which blood tests do I need?

You need results from a chemistry panel, a complete blood count (CBC) with differential, and a separate CRP test if it is not included. Specifically: albumin, creatinine, fasting glucose, C-reactive protein (CRP), lymphocyte percent, mean cell volume (MCV), red cell distribution width (RDW), alkaline phosphatase (ALP), and white blood cell count (WBC).

What units should I use?

The equation is calibrated to specific units (albumin g/L, creatinine µmol/L, glucose mmol/L, CRP mg/dL, and so on). To avoid mistakes, the four fields with alternative units have toggles. Switching a toggle converts the displayed measurement; always match your lab report before entering a new value.

Is this the same as an epigenetic clock?

No. PhenoAge here is computed from blood biomarkers, not DNA methylation. The same 2018 paper also trained an epigenetic 'DNAm PhenoAge' clock, but this tool uses the original blood-based phenotypic-age equation, which anyone with a standard lab panel can compute.

Is this medical advice?

No. This is an educational estimate using a published research equation. It is not a diagnosis, not a mortality prediction for you as an individual, and not a substitute for a clinician interpreting your labs in context.

Interactive tool · Biological age

Biological Age Calculator

By Longevity Graded · Revised October 2026

Enter nine routine blood-test results and your age to get your PhenoAge, from the published Levine equation. The math runs in your browser.

Educational content, not medical advice. Talk to a licensed clinician before starting any treatment. How it works and its limits

Example values are prefilled. Replace all ten fields with your own results and check each lab unit. Switching units converts the number already entered.

Chronological ageyrYour actual age in years (20–100; this tool’s supported range).AlbuminA blood protein. US labs report g/dL (e.g. 4.7); SI is g/L (×10).CreatinineA kidney-function marker. US mg/dL (e.g. 0.8); SI µmol/L (×88.4).Fasting glucoseBlood sugar. US mg/dL (e.g. 99); SI mmol/L (÷18).C-reactive protein (CRP)An inflammation marker. Most US labs report mg/L (e.g. 1.0). Must be above 0.Lymphocyte percent%Lymphocytes as a % of white cells (from a CBC with differential).Mean cell volume (MCV)fLAverage red-blood-cell size, in fL.Red cell distribution width (RDW)%Variation in red-cell size, as a % (from a CBC).Alkaline phosphatase (ALP)U/LA liver/bone enzyme, in U/L (= IU/L).White blood cell count (WBC)10³/µLIn 10³ cells/µL — e.g. enter 5.0 for 5,000/µL.

PhenoAge estimate

30.9yr

This blood-based estimate is younger than the entered chronological age — about 9.1 years younger.

PhenoAge minus chronological age

−9.1yr

Compared with the entered age of 40. This is simple subtraction, not the regression-adjusted PhenoAgeAccel measure used in research.

PhenoAge: 30.9 yr; Levine phenotypic age
Linear score (xb): -10.058; weighted biomarker sum
10-yr mortality score: 0.84%; model-implied, not a forecast

How it is calculated. Nine blood markers and age enter a mortality-trained research equation. The source, units, coefficient convention and an illustrative calculation are documented below. Results describe the model; they do not measure how many years you have gained or lost. Lab inputs are calculated locally in this tool and are not submitted by the calculator.

About this tool

This tool estimates clinical phenotypic age from nine blood biomarkers and chronological age. It follows the original 2018 supplementary methods at their published precision. It does not measure DNA methylation or predict an individual's remaining lifespan.

Read before you use this

This is an educational research calculator, not a medical assessment. PhenoAge is a population model: it estimates biological aging from group-level mortality data and is not a personal mortality prediction. A single panel is a snapshot — acute illness, infection, dehydration, recent exercise, or a lab error can swing CRP, WBC and glucose and distort the result. Biological age is one of many signals, not a verdict. Always have a licensed clinician interpret your bloodwork in the context of your full health history, and never start, stop, or change treatment based on a number from this tool.

Which model this is — in plain terms

We use Table S1 of the original 2018 supplement for the coefficients, including intercept −19.9067 and ALP 0.0019, with γ = 0.0076927 from its methods and 0.090165 in the final conversion. Other publications and calculators use different rounding or constants, so results may differ. This convention is fixed and shown below.

The formula and source convention

Values below follow the original supplement's Table S1 and methods, rather than mixing constants from different versions. The calculator converts units before applying the weighted sum and the two mortality-model transformations.

Biomarker	Coefficient	Required unit
Intercept	−19.9067	—
Albumin	−0.0336	g/L
Creatinine	+0.0095	µmol/L
Fasting glucose	+0.1953	mmol/L
ln(C-reactive protein)	+0.0954	CRP in mg/dL, natural-log transformed
Lymphocyte percent	−0.0120	%
Mean cell volume (MCV)	+0.0268	fL
Red cell distribution width (RDW)	+0.3306	%
Alkaline phosphatase (ALP)	+0.0019	U/L
White blood cell count (WBC)	+0.0554	10³ cells/µL
Chronological age	+0.0804	years

Step 1 — linear score (xb). Multiply each biomarker by its coefficient above, in the required unit, and sum them with the intercept:

xb = −19.9067 − 0.0336·albumin + 0.0095·creatinine + 0.1953·glucose + 0.0954·ln(CRP) − 0.0120·lymph% + 0.0268·MCV + 0.3306·RDW + 0.0019·ALP + 0.0554·WBC + 0.0804·age

Step 2 — 10-year mortality score (M). Pass xb through a Gompertz transform, with γ = 0.0076927 and t = 120 months:

M = 1 − exp( −exp(xb) × (exp(0.0076927 × 120) − 1) / 0.0076927 )

Step 3 — PhenoAge. Rescale the mortality score into an age-equivalent number:

PhenoAge = 141.50225 + ln( −0.00553 × ln(1 − M) ) / 0.090165

That's the entire model — no other inputs, no hidden weighting, no proprietary adjustment. Anyone with the nine lab values above and a calculator can reproduce our tool's output by hand.

An illustrative calculation

These are synthetic inputs, not a participant or worked example from the paper: age 40; albumin 47 g/L; creatinine 71 µmol/L; glucose 5.5 mmol/L; CRP 0.1 mg/dL; lymphocytes 33%; MCV 90 fL; RDW 13%; ALP 50 U/L; WBC 5 × 10³/µL.

They give xb = −10.0551166, mortality score = 0.008437756 (about 0.844%), and PhenoAge = 30.9452 years, displayed as 30.9. These intermediate values were independently recalculated from the source equation and are covered by automated tests.

The prefilled form uses creatinine 0.8 mg/dL, equivalent to 70.736 µmol/L rather than 71. It also rounds to 30.9 years. The difference from chronological age is simple subtraction, not the age-adjusted regression residual called PhenoAgeAccel.

Questions, answered

What is PhenoAge?: PhenoAge (phenotypic age) is a published measure of biological age developed by Morgan Levine and colleagues in 2018. It combines nine routine clinical blood biomarkers and your chronological age into a single 'age-equivalent' number, trained on NHANES mortality data. The estimate reflects the model's age-equivalent risk pattern; it is not a measurement of your actual lifespan.
Which blood tests do I need?: You need results from a chemistry panel, a complete blood count (CBC) with differential, and a separate CRP test if it is not included. Specifically: albumin, creatinine, fasting glucose, C-reactive protein (CRP), lymphocyte percent, mean cell volume (MCV), red cell distribution width (RDW), alkaline phosphatase (ALP), and white blood cell count (WBC).
What units should I use?: The equation is calibrated to specific units (albumin g/L, creatinine µmol/L, glucose mmol/L, CRP mg/dL, and so on). To avoid mistakes, the four fields with alternative units have toggles. Switching a toggle converts the displayed measurement; always match your lab report before entering a new value.
Is this the same as an epigenetic clock?: No. PhenoAge here is computed from blood biomarkers, not DNA methylation. The same 2018 paper also trained an epigenetic 'DNAm PhenoAge' clock, but this tool uses the original blood-based phenotypic-age equation, which anyone with a standard lab panel can compute.
Is this medical advice?: No. This is an educational estimate using a published research equation. It is not a diagnosis, not a mortality prediction for you as an individual, and not a substitute for a clinician interpreting your labs in context.

Put the number in context

A bio-age number is only useful if you know what drives it and how it compares to the other ways of measuring aging:

Reference

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018 Apr 18;10(4):573–591. PMID 29676998. See the original supplementary methods (PDF), pages 1–2 and Table S1 on page 10.

This calculator is informational and not medical advice. It applies a published research equation to lab values you enter and does not account for your individual health history, medications, acute illness, or lab-method differences. It is not a diagnosis and not a personal mortality prediction. Consult a licensed clinician to interpret your bloodwork and before making any health decisions.